BIOLOGY 454S
Physiological Genetics of Disease
H. Frederik Nijhout
Description from DukeHub
An exploration of how we have come to understand the relationships between genes and traits, with a focus on traits of biomedical importance. We explore how physiological systems biology can be used to understand the causal pathways by which genes affect traits. Examples will be taken largely from the biomedical literature with a focus on genetic diseases and the roles of genetic background and environment in determining how (and why) genes affect traits. Readings and class participation, short papers and oral presentations on research projects. Recommended prerequisite: Biology 203L or 201L and 202L and Mathematics 112L.
Skills
- writingAI review: "short papers"
- public speakingAI review: "oral presentations on research projects"
AI-resilient: 1 of 5
- No: Physical, lab or field work
- No: Live work with people
- No: Judgment someone is accountable for
- No: A craft you practice with your hands or body
- Yes: Small, in-person format · seminar, 12 seats per section
The checks lean on Microsoft Research, Working with AI (2025), which found generative AI applies least to physical work and hands-on work with people. A signal, not a promise. How the score works
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